Despite induced basal defences in T200, these PRPs are not capable of inhibiting viral replication and spread, as demonstrated by the progressive increase in symptom severity, virus titre and high number of repressed genes over the infection period.
Further content validity was demonstrated by the progressive lower correlation between the subscales of the PCRT with the prostate cancer questionnaire (PCQoL), the general cancer questionnaire (FACT-G©), and a general health questionnaire (SF-36®).
The adequacy of the procedure has been demonstrated by studying the progressive collapse behavior of a typical RC framed high-rise building in Riyadh when exposed to blast generated waves.
When subjected to hepatogenic differentiation on untreated plastic support, UCMSCs differentiated in hepatocyte-like cells as demonstrated by their morphology, progressive up-regulation of mature hepatocyte markers, glycogen storage, albumin and urea secretion.
Nine patients (21%) achieved a partial response, 26 (62%) remained stable and five (12%) showed progressive disease demonstrated by the development of distant metastases.
The effect is progressive, as demonstrated by the slow development of amphetamine-induced rotational behavior, and primarily affects nigrostriatal axonal projections.
The complete loss of claudin-16, as demonstrated by immunostaining, may thus cause progressive nephron loss with tubular atrophy and interstitial fibrosis and secondary glomerular damage.
All patients had progressive disease as demonstrated by a PSA increase on two or more consecutive measurements taken at least 7 days apart.
Comp T585M mutant mice, which we have previously characterized as a relevant model of mild PSACH (20), also suffer from a progressive myopathy as demonstrated by grip strength testing.
The clinical relevance of BSEP in bile salt secretion in man has also been demonstrated by several genetic traits, such as progressive familial intrahepatic cholestasis type 2 (PFIC2), benign recurrent intrahepatic cholestasis (BRIC), and intrahepatic cholestasis of pregnancy (ICP) (for review see [ 2, 3]).
