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The complexity of aberrant gene interactions associated with metastasis has been demonstrated by multiple studies.
Significantly, the importance of identifying rare point mutations in ASD has been demonstrated by multiple studies.
The nephrotoxicity of high molecular weight and high substitution rate HES administered at high posology in patients with severe sepsis and septic shock is demonstrated by multiple studies.
The connection between cadherin-catenin proteins and the Hippo pathway components has been demonstrated by multiple studies and we will discuss these findings in more detail (see below).
Indeed, restoration of wild-type WRN expression would rescue the aging-associated phenotypes caused by WRN deficiency, as demonstrated by multiple studies that lentiviral/retroviral delivery WRN gene can rescue the phenotypes [ 18, 69, 70].
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The usefulness of new measures is therefore demonstrated by multiple applications in different studies (accumulative body of evidence to support scale measurement properties).
In this study we demonstrated by multiple linear regression analysis, an independent association between serum levels of anti-CCP antibodies and cIMT after adjustment for age, gender, and disease activity.
The beneficial treatment effect for decreasing de novo adhesions at second-look hysteroscopy is robust as demonstrated by multiple sensitivity analyses evaluating the influence of study quality, choice of the analysis model for data synthesis, and the choice of the summary effect measure.
This is evidenced by multiple studies demonstrating glial differentiation of neural stem cells [8], adult spinal cord progenitor cells [7], [9], [10] and human embryonic stem cell-derived oligodendrocyte progenitor cells [5] following transplantation into injured spinal cords.
The central role of TGF-β in promoting fibrovascular pathology and subsequent organ dysfunction has been reinforced by multiple studies demonstrating the beneficial effects of blocking TGF-β for either chronic renal [28], [29] or cardiac disease [30], [31].
The significant impact of moderate hypoglycemia while driving is supported by multiple studies demonstrating that moderate hypoglycemia significantly and consistently impairs driving safety (24– 26) and judgment (27, 28) as to whether to continue to drive or to self-treat (29, 30) under such metabolic conditions.
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