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To determine if a discrete portion of this region binds ferritin, we made further truncation constructs and demonstrated binding to amino acids 475 522.
Thermal denaturation and CD titration studies demonstrated binding to the cognate sequence (5′-AAGCTA-3′).
TS1 exhibited a distinct cytoplasmic pattern of staining in viable tumour cells, but also demonstrated binding to necrotic regions and pyknotic/apoptotic tumour cells (Figure 1).
Second, tau protein is demonstrated binding to the minor groove of dsDNA without nucleotide sequence specificity (Figures 4 6).
Intact trastuzumab demonstrated binding to all three FcγRs in a concentration-dependent manner.
DmsD has demonstrated binding to the preprotein form of TorA and its signal peptide [ 16, 24].
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Antibody-labeled MNPs (Alexa647 chick MNPs) were used to preconcentrate the target via magnetic separation and as the tracer to demonstrate binding to slides modified with anti-chicken IgG as a capture agent.
An NMR solution of the vertebrate CstF-64 RRM structure was used to demonstrate binding to either (GU 4 or (GU 4UG, with a preference for the latter [ 22, 23].
Modelling of the structures bound to the cognate 50S ribosome target demonstrates binding to the same site as linezolid is possible.
Such extensions can involve interactions with additional sugar residues in an oligosaccharide ligand, but an increasing number of examples demonstrate binding to other modifications of the sugars.
More recent studies show that ponezumab labels amyloid plaques in 14-month-old Tg2576 mouse and human AD brains [ 207], demonstrating binding to fibrillar Aβ.
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