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Exact(2)
One quality assessment item was omitted ("Was a dose response relationship between exposure and outcome demonstrated?") because this item relates to the findings of the study and not the methodological quality, and assessment of dose response forms part of the Bradford Hill criteria for causation (see below).
Notwithstanding this suggestion, it is clear that similar patterns of accumulation in each tissue type must first be demonstrated, because this study showed some tissue differences in the pattern of EDC concentrations and certain tissues, such as testis tissue, exhibit a lower rate of accumulation of some EDCs (Cooke et al. 2001).
Similar(58)
This was demonstrated because the benefit of the NOACs with an 80% reduction in preventing recurrent venous thromboembolic events exceeded the risk of major bleeding and because the net clinical benefit was evident for rivaroxaban and apixaban compared with placebo [ 20, 21].
The criterion validity is demonstrated because the validated IFSAC correlates well with the criterion.
Indeed, no causal relationship has been demonstrated because the study design was cross-sectional.
For example, the effect of mutation IVS9 +43c on the mRNA splicing cannot be directly demonstrated because the aberrant mRNA transcript cannot be obtained.
Intriguingly, the lack of specificity was demonstrated because the D-allo-ShK was still able to block several K+ ion channels with high affinity [40,42].
A sensitivity advantage for sdLCS could not be demonstrated, because the quantum efficiency of the spectrograph is not optimized for these experiments.
This statement was not directly demonstrated because of the difficulty to simultaneously measure on individual cells both the number of virions produced and cell fluorescence.
We anticipated that differences in fasting glycemia might be demonstrated because of difference in duration of action, but this was not observed in the fasting glucose from SMBG profiles.
This equivalence could not be demonstrated because of a high MPE for EV and TTE if LVSV was determined by M-mode (EVMM), except in the OTX and NEURO subgroups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com