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Superior efficacy of E/C/F/TAF compared to E/C/F/TDF was demonstrated at Week 144 with 84% treatment success compared to 80%, respectively, along with significantly better outcomes of bone and renal safety.
The improvement from baseline scores demonstrated at week 4 in both groups remained significant for most outcomes at week 8.
Small dose-related increases in 24-h urine volumes (range 107 470 ml above baseline of 1.8 2.2 l) were demonstrated at week 12. Increases in hematocrit were also dose-related (range 1.5 2.9%).
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17 As already demonstrated at 18 weeks, the 33-week analysis confirmed the superiority of pramipexole ER over placebo (adjusted mean change in UPDRS II + III score: −8.2 ER vs −1.2 placebo [ P < 0.0001]).
Median PFS was demonstrated at 12.0 weeks, median time to PSA progression 17.4 weeks, and median OS 31.6 weeks.
Scaffold fixation and early integration was demonstrated at 2 weeks post implantation.
Noninferiority and superior HbA1c reductions with both taspoglutide 10 and 20 mg compared with exenatide were demonstrated at 24 weeks.
Reproducibility of the WORC has been demonstrated at 2 weeks and 3 months (0.96 and 0.93 respectively) [ 48].
The development of cardiac hypertrophy was previously demonstrated at 8 weeks of age in male offspring (13).
Patients 5 and 4 demonstrated seroconversion at week 7 and 8 of illness, respectively.
11 Increases in BAP levels have also been demonstrated at 36 and 52 weeks following anti-TNFα therapy.
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