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Approval of new drugs requires either two randomised clinical trials in which the new drug demonstrates efficacy at a two-sided level 0.05 or one larger trial in which efficacy is demonstrated at a level comparable with two trials each at 0.05.
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Performance is demonstrated at a high level.
Thus, the repetition enhancement effect first demonstrated at a subcortical level by Chandrasekaran et al. (2009) seems to generalizes to repetition occurring in a number of different forms, such as single sound played repeatedly (i.e., the 'da' sound in [1]), a repeating melody, and a repeating note within a melody.
We therefore investigated whether a similar finding could be demonstrated at a subcellular level, by quantifying the 2 slowly diffusing species detected by FCS with a fluorescent antagonist (CA200645).
While overlapping ASL perfusion abnormalities relative to FDG were demonstrated at a group level, future studies are necessary to clarify the clinical potential of this application for single subjects, while also controlling for common confounding effects.
In this work, we have demonstrated at an enzymatic level that TFV is activated in a tissue-specific manner.
This is similar to what has been demonstrated at a single cell level for somatosensory stimuli in the primary somatosensory cortex: stimulus intensity is coded in the primary somatosensory cortex, the conscious percept per se in the prefrontal cortex [23].
Here and in recent studies by Ahluwalia et al [ 23] and Stahlberg et al [ 8], the significance of this regulation is demonstrated at a more comprehensive level and novel hepatic gender-regulated genes are identified.
In the present study, the down regulation of prostaglandin F synthase (K15717) by increasing dietary DHA was consistent with inhibited production of prostaglandin F, albeit this time demonstrated at a gene transcriptional level.
Implications of the translated and validated questionnaire can be demonstrated at a local, national and international level.
It demonstrates at a high level how context influences business and, in turn, how leaders can influence context.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com