However, despite the fact that hand hygiene has been demonstrated as the single most important strategy to prevent and control healthcare associated infections and spread of multi-drug resistance organisms in healthcare settings, studies have shown that hand hygiene compliance remains suboptimal [ 2- 4].
With IL-8 being currently demonstrated as the single most up-regulated gene in surgically resected GC tumors, the up-regulation of this gene throughout gastric cancer progression may constitute an early and important event in the disease, initiated and maintained by H. pylori infection.
Moreover, Irinotecan demonstrated activity as single agent in pretreated patients (Sanchez et al, 2003).
We demonstrated that, as single agents, sunitinib, sorafenib and everolimus share similar activity in inhibiting cell proliferation, signal transduction and vascular endothelial growth factor (VEGF) secretion in different RCC models, both in vitro and in tumour xenografts.
Several antiangiogenic agents blocking either VEGF or VEGFR have been tested in advanced prostate cancer but none of them have so far demonstrated activity as single agents (Aragon-Ching et al, 2010).
Given their demonstrated activity as single agents and toxicity profiles, including myelosuppression and gastrointestinal adverse effects, most studies focus on maintenance treatment after chemotherapy rather than combinations with antineoplastic drugs.
Capecitabine is an orally administered fluoropyrimidine that is converted by 5-FU by thymidine phosphorylase (TP), preferentially in tumor tissues and has demonstrated activity as single agent in patients with gastrointestinal cancers.
Cells within individual CCO-deficient patches were demonstrated as clonally derived by single cell laser microdissection and subsequent mitochondrial genome sequencing.
Therefore, like the case of being conditioned and being impermanent, the relation between the two truths is demonstrated as one of a single ontological identity.
Immunomodulatory drugs (IMIDs) and proteasome inhibitors have demonstrated effectiveness, as single-agent or combination regimens, in rrMM.
