The results of the study failed to demonstrate any impact of MK-329 on tumor progression, pain, or nutrition.
It is noteworthy that two recent studies failed to demonstrate any impact of RRT modalities on renal recovery [35, 36].
Although neutropenia is an independent risk factor for poor outcome in the general ICU population with severe sepsis or septic shock [6] and in earlier cohorts of critically ill cancer patients [12, 13], several recent studies failed to demonstrate any impact of neutropenia, neutropenia duration, or resolution of neutropenia on the outcome of critically ill cancer patients [7, 14 24].
However, similar public health initiatives in Australia [ 11] and Canada [ 12] have failed to demonstrate any impact on DUP.
Another similar study in Nottingham, however, failed to demonstrate any impact on staff absence during influenza epidemic seasons of 1993 94 and 1996 97 [ 19].
Follow-up, therefore, is long enough to demonstrate any impact of this new therapy on survival, and the data are mature for final analysis.
A number of studies have failed to demonstrate any impact of body mass on intensive care outcome [ 7- 11], whereas others have demonstrated an association between obesity and increased risk-adjusted mortality [ 12- 14].
A prospective study in 686 patients with stable congestive heart failure did not demonstrate any impact of the C34T polymorphism on tested clinical, biochemical, echocardiographic, radionuclide or exercise parameters [ 10].
Although the SUPPORT model has been well validated [ 17, 22] for prognostication of LE in terminally ill patients, a controlled trial of SUPPORT failed to demonstrate any impact on the overall quality of care for these patients [ 17, 20].
This randomised trial failed to demonstrate any impact of opportunistic referral of smokers for telephone-delivered smoking cessation advice by a nurse on subsequent quit rates or smokers' stage of change.
