Schall's group was the first to demonstrate an implication of CXCR7 in physiological and pathological processes, including cell growth/survival and adhesion, as well as promotion of tumour growth (Burns et al, 2006).
Furthermore, intensive studies on Rab3 and Rab27 subfamily members clearly demonstrate an implication of both in regulated secretion, although the involvement of these proteins in specific steps of SG traffic remains unclear.
Rothman (1974) demonstrated an important implication of RDA for this situation in an interesting thought experiment.
Recently, a combination of genetic and functional genomic studies demonstrated a major implication of the factor Zelda between one and three hours after fertilisation [ 7].
Moreover, BMIPP imaging demonstrated a higher severity score compared with 99mTc-SPECT and had incremental prognostic implications as demonstrated by Kontos et al. in a multicenter study performed on 507 patients [ 73].
Finally, in terms of biological functions, a lot of studies demonstrated the implication of class I proteins in chemotaxis in Dyctiostelium [ 39– 41].
In a previous report, we demonstrated the implication of both farnesylated and geranylgeranylated proteins in E2 actions, as prenylation inhibitors block the cell-cycle progression driven by E2 and stimulate the transcriptional activity of the ER [ 17].
In addition to a demonstrated implication of such candidate genes, family-based segregation and linkage analyses have repeatedly identified the importance of the chromosomal region 5q31-33 in the control of parasite density, with heritability exceeding 40% [7] [11].
Furthermore, our experiments using a neutralizing antibody or recombinant protein demonstrated the implication of autocrine IL-6 signalling in STAT3 activation in human gastric cancer cells.
Moreover, concomitantly with our work, it has been demonstrated the implication of human transporters in tumor progression in a transport-independent manner.
