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Clinical studies have demonstrated activity of IA chemotherapy approaches for low- and high-grade gliomas, cerebral lymphoma, and brain metastases.
In trying to envision a "best case" scenario, we should consider the already demonstrated activity of L1 RTEs during cancer development, and in the nervous system.
Phase II trials demonstrated activity of nitrosoureas, such as FTM, in relapsing GBM patients previously treated with TMZ plus radiotherapy as first line treatment [ 4].
Nevertheless, this result is consistent with the demonstrated activity of hRev1 as a specialized dCTP transferase, preferentially inserting dCTP opposite damaged or undamaged templating bases.
Studies of docetaxel and vinorelbine in metastatic breast cancer have demonstrated activity of both drugs as single agents and in combination.
Beyond its use in the management of colorectal cancer, the recently demonstrated activity of irinotecan in small-cell lung cancer and glioblastoma may give TDP1 a broader utility.
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Although, a great number of scientific researchers demonstrated activities of several African plants, few of them venture into studying their toxicity.
The experimentally demonstrated activities of ribozymes include, among others, those that are involved in the main chemical steps of translation, such as amino acid activation, RNA aminoacylation, and peptidyl transfer [ 45- 48].
Other than functional information on the myocardial activity from MRI, PET can demonstrate activity of the inflammatory process in the myocardium (Fig. 11).
This clearly demonstrates activity of overexpressed JNK3 kinase.
Zinzani et al reported the first study to demonstrate activity of lenalidomide in T-cell lymphoma.
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