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The R11E mutant was found to have activity near that of wild-type ImI, while R7L and D5N demonstrated activities reduced by at least two orders of magnitude.
Among the eight traditional medicinal plants that demonstrated activities in increasing anti-insulin resistance bioactivity or enhancing glucose uptake, six were identified as effective according to the GCA indicator including C. chinensis, M. alba, P. lobata, T. kirilowii, A. orientale and S. chinensis.
The IG neurons shown in Fig. 2D F demonstrated activities specific for 2, 4, and 7 s by increased firing during the interval-response period (Fisher's SLD test, P<0.05).
While in our study we used 10 model substrates to monitor the substrate specificity of FAEs there are more than 30 substrates where FAEs have demonstrated activities [17] and is general belief that there are many more to be discovered.
One such candidate is glial cell line-derived neurotrophic factor (GDNF) given its spectrum of demonstrated activities which includes, but is not limited to, potent trophic actions on a wide variety of neuronal populations of the central and peripheral nervous systems [1].
Although, a great number of scientific researchers demonstrated activities of several African plants, few of them venture into studying their toxicity.
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Many plants and their active chemical compounds have demonstrated activity in the treatment of various disorders [ 3].
But a few, apparently rehabilitated, demonstrated activity: a faint plume, a nearby tent.
(Lauraceae) demonstrated activity against Trypanosoma cruzi.
Both steroids demonstrated activity against Leishmania (L).
Compounds 2 - 5 demonstrated activity against Staphylococcus aureus.
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