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This interaction between growth factors and PRs was recently confirmed by Labriola and coworkers [ 18], who demonstrated activation of PRs by mitogen-activated protein kinase (MAPK) using both our murine cells and T47D human cells; and by Qiu and coworkers [ 19], who demonstrated that activation of MAPK in human cells induced Ser294 phosphorylation and rapid nuclear translocation.
A potential role for regulation of SREBP by Akt was revealed in a study that demonstrated activation of SREBP in cells expressing activated Akt, resulting in the induction of 24 genes involved in sterol/fatty acid biosynthesis and a statistically significant increase in saturated fatty acids in these cells [ 100].
Therefore, we concluded that active B cells in SLE patients demonstrated activation of AKT signaling leading to decreased P53 expression, which then decreased the expression of miR-1246 and enhanced the expression of EBF1 which contributed to a further activation of B cells.
Recent studies have demonstrated activation of Wnt/β-catenin pathway by RAS in CKD.
We demonstrated activation of sensory neurons by microbes, correlating with RORg+ Treg induction.
Enhanced EEA in three aggregate size classes demonstrated activation of microorganisms by roots.
Among the signaling pathways induced at birth, we demonstrated activation of UPR in alveolar epithelial cells, which was accompanied by increased expression of TFs regulating surfactant protein and lipid biosynthesis.
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Indeed in the study demonstrating activation of NFkB, it was found that mutant Htt associated with and activated IKKγ (Khoshnan et al. 2004).
In summary, our data demonstrate activation of oval cell response after gene transfer of thymidine kinase followed by ganciclovir administration.
First study demonstrating activation of IRE-1 not via its luminal domain but via its cytoplasmic domain, suggesting the existence of alternative ways to trigger sensors that detect the UPR.
By modelling and experiment, we demonstrate activation of a known photosensitizer, chlorin e6, by in situ nonlinear optical upconversion of near-infrared laser radiation using second-harmonic generation in collagen and four-wave mixing, including coherent anti-Stokes Raman scattering, produced by cellular biomolecules.
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