We attempted to address the possibility of false-positives and the effects of multiple testing by demonstrating a significant P-value in the permutation test.
The variation of VAS demonstrated a significant decrease (p-value: 0.001 and p-value: 0.037) between two groups after two different durations: 30 mins and 7 days.
It is clear from this figure that a replication study will need to involve at least 2000 cases and 2000 controls if it is to have >95% power to demonstrate a nominally significant P-value of 5%.
*denotes a significant p value.
* indicates a significant p value.
To decide whether a gene for a given comparison was to be considered "differentially expressed," we adopted a "strict consensus" criterion wherein the gene was required to demonstrate a significant FDR-adjusted p-value across all 4 absolute analysis datasets.
> -wrap-foot> A * demonstrates a statistically significant P value of <0.05 when compared to vehicle-treated cells.
We attempted to address the possibility of false-positives and the effects of multiple testing by demonstrating a borderline significant P value in the permutation test.
With a less significant P-value, the A2A-2 haplotype, which comprises the rs9624472 A and rs5751876 T alleles demonstrated risk to severe malaria [OR = 1.14 (1.02–1.28), P = 0.019].
Our results demonstrated a significant enrichment (Benjamini-Hochberg adjusted P-value < 0.05) in all 3 categories of GO terms: cellular component, molecular function, and biological process (Fig. S3).
