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The pairwise comparisons between the different time points demonstrated a significant fall of BMD of the Charcot foot from presentation to clinical resolution (P = 0.015).
The multivariate analysis demonstrated a significant fall of BMD of the Charcot foot from the time of presentation to the time of clinical resolution (Wilks Λ = 0.525, P < 0.001).
The 30-day mortality of all patients attending the AAU or CAU was calculated and also demonstrated a significant fall, from 5.8%to4.4%4% (a relative reduction of 24%; see online supplementary appendix figure S3).
Indeed a recent report [ 24] demonstrated a significant fall in stillbirth rates in areas of the UK which had adopted the use of customized growth charts to detect IUGR in pregnancy compared to those with low uptake, suggesting that intervention in this area is both possible and successful.
However, we have clearly demonstrated a significant fall in the proliferation in DCIS epithelium following a period of oestrogen withdrawal in OR-positive (but not in OR-negative) tumours, consistent with that reported in OR-positive IBC after treatment with either aromatase inhibitors (Ellis et al, 2001; Miller et al, 2001) or tamoxifen (Chang et al, 2000).
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The blood conservation device group lost significantly less blood for diagnostic testing (63 ml vs. 133 ml for controls), but the study failed to demonstrate a significant fall in Hb levels between admission and discharge when comparing the two groups [24].
If there is no doubt that cytokines could be removed by CVVH then reports demonstrating a significant fall in the serum levels of inflammatory mediators are scarce, especially during CVVH with a 'conventional' substitution rate (< 2.5 l/hour) [ 10, 23- 27].
The blood conservation device group lost significantly less blood for diagnostic testing (63 ml vs. 133 ml for controls), but the study failed to demonstrate a significant fall in Hb levels between admission and discharge when comparing the two groups [ 24].
Two meta-analyses of observational studies found both a slight to moderate increased risk of falls with antihypertensive treatment [ 20, 21] and van der Velde and colleagues demonstrated a significant reduction of falls after withdrawal of cardiovascular medications [ 22].
Recent evidence from the UK specifically addressing interventions offered to non-conveyed fallers also supports this multidisciplinary approach and demonstrated a significant reduction in falls and a positive effect on patient health outcomes as a result of the intervention [ 17].
LUTs were reported by 91% of participants; we demonstrated a significant association between overall LUTS and the symptoms that comprise falls risk at baseline and second (three month) follow up visit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com