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However, imaging and surgical series have demonstrated a high frequency of prostatic lymph node (LN) drainage beyond these landmarks.
The biochemical characterization of the isoenzymes demonstrated a high frequency of the phenotype A− G6PD deficiency.
Another group demonstrated a high frequency of medulloblastomas in mice through co-overexpression of Shh and hepatocyte growth factor, HGF, the ligand for the transmembrane receptor c-Met.
Analysis of the copy number data from the Rembrandt dataset demonstrated a high frequency of large losses of chromosomes 1p and 19q in oligodendrogliomas, but not in astrocytomas or GBMs.
We have previously demonstrated a high frequency of ACVR2 mutations in MSI-H colon cancers in conjunction with loss of ACVR2 protein expression [2] and association with larger colon tumors and poorer histologic grade [14].
Several groups have demonstrated a high frequency of somatic gene methylation in CRC, and transcriptional silencing in the tumor cells has been reported for an increasing number of genes, including p16INK4, MGMT, GSTP1, CDH1, APC and TIMP3 among many others [10], [11].
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Interestingly, TMJ OA patients were mostly associated with somatosensory gain of function (hyperalgesia) when compared with arthralgia patients, whereas arthralgia patients demonstrated a higher frequency of negative somatosensory signs compared with OA patients.
This speculation is also supported by a European study that demonstrated a higher frequency of alcohol dehydrogenase-1B (ADH1B, previously called ADH2) His allele (rs1229984) in migraineurs who reported triggering of migraine attacks by alcohol than in migraineurs who reported no effect of alcohol [14].
Therapy naïve co-infected individuals demonstrated a higher frequency of intra-hepatic CD8+ T-cells that produce TNF-α in response to both HCV and HIV antigen stimulation compared to HCV mono-infected individuals.
Of 192 patients, 182 demonstrated a higher frequency of CD25brightCD4+ T cells in synovial fluid than in peripheral blood.
In conclusion, they demonstrated a higher frequency of appropriate ICD therapy and a shorter event-free survival in chagasic than in nonchagasic patients.
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