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In vitro studies of the past decade have demonstrated a function of ZO-1 in organisation of confluent cell layers.
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These results demonstrate a function of USP13 in ERAD downstream of retrotranslocation and suggest a potential functional interplay between USP13 and Bag6 that is required to maintain retrotranslocated substrates in a soluble and degradable state.
To demonstrate a function of Tin2 in the plant cytosol, we expressed tin2 without its secretion signal under the CaMV 35S promoter in maize leaf epidermal cells after biolistic bombardment.
A hydrophobic pocket at the inside of the concave surface is open in the presence of an internal peptide ligand and closes in the absence of this ligand, and we demonstrate a function of this pocket in the inhibition of ASIC3 activity.
Moreover, gain-of-function experiments have demonstrated a role of Nanog and Oct4 in promoting cellular proliferation [49].
Significant tunability of graphite exfoliation and property enhancements is demonstrated as a function of SSSP processing.
The carbon monoxide elimination efficiency was demonstrated as a function of the [Mn]/[Cu] ratio and reaction time.
Pore expansion of fluorinated surfactant templated mesoporous silica powders is demonstrated as a function of pressurized CO2 processing conditions.
which is the ratio of the channel average rate, e.g., (21), and the one for uncorrelated channels, e.g. (28), is demonstrated as a function of the channels correlation.
In addition to S-nitrosoglutathione reductase (GSNOR), a ubiquitous and well-conserved SNO-metabolizing enzyme (20), denitrosylation has also been demonstrated as a function of the thioredoxin/thioredoxin reductase system (21).
More recently, it was demonstrated that a function of PARP in NER DNA repair and clinical grade PARP inhibitors in association with chemotherapy could reverse the resistance of CLL cells to DNA crosslinking agents [ 47].
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