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The drugs, sold under brand names such as Abilify, Seroquel, and Zyprexa, had been tested on schizophrenics in several large clinical trials, all of which had demonstrated a dramatic decrease in the subjects' psychiatric symptoms.
Furthermore, while L858R-treated tumor cells demonstrated a dramatic decrease in phospho-EGFR staining (Figure 5B), the treated C/L858R+T790M tumor cells continued to display reactivity with phospho-EGFR antibody.
As a result, TAP-Lxn cells demonstrated a dramatic decrease in the fraction of S phase after irradiation.
Seven days after surgery, walking track analysis demonstrated a dramatic decrease of SFI to approximately −78.48 ± 2.4, indicating complete loss of function.
In accordance with our in vitro findings, immunohistochemistry of 4T1 tumors demonstrated a dramatic decrease in the phosphorylation of p38 MAPK and Smad2 with FAK depletion.
Schmidt demonstrated a dramatic decrease in CBF following the administration of a large (10 mg/kg) dose of racemic ketamine [ 33].
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Our data demonstrate a dramatic decrease in the primary expansion of naïve T cells when cultured with HIV-1-exposed DC.
Taken together, our results clearly demonstrate a dramatic decrease in the migratory capacity of TSPC during aging and suggested that distorted actin dynamics might be a core reason.
While morphological imaging does not show changes, [F]FDG PET demonstrates a dramatic decrease in metabolic rate, which appears helpful in the early identification of responders [ 6, 7].
In vitro functional analysis has been performed for some of these mutations (p.Asp200Asn, p.Asp201ins, and p.Val201Asp), demonstrating a dramatic decrease (from 4-fold for p.Val201Asp up to 35,000-fold for p.Asp201ins) in the exonuclease activity [ 13, 14].
This scenario is supported by experiments demonstrating a dramatic decrease in the stability of the c-oligomers of Na+-translocating F-ATPases from I. tartaricus and P. modestum in the absence of Na+ [ 56].
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