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We have designed and demonstrated a discovery pipeline for alternative splice variant (ASV) proteins from tandem MS/MS datasets.
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The discovery demonstrated a new function of murine Retn and suggested that it could potentially accelerate bone marrow regeneration post chemotherapy.
While the above discovery demonstrated a role for RNAi in epigenetic silencing, the nature of this role and mechanisms for interaction between RNAi and chromatin machineries were less clear.
The present study demonstrated a novel technique for biomarker discovery.
This model demonstrated a robust performance in the discovery (AUC = 0.952) and verification (AUC = 0.980) phase with a high separation power independent from gender.
To this end, we have demonstrated a strategy to reduce false discovery and improve the accuracy of antibody identification by shotgun proteomics through the use of high mass accuracy LC-MS/MS and high stringency filters applied to groups of peptide-spectral matches, rather than individual PSMs.
THes article originally appeared on VICE US.
Collectively, this study demonstrates a new method for discovery of DAACPs using IMS technique with the ability to localize d-amino acid residues.
At a practical level we demonstrate a methodology for drug discovery using these cells, based on high content screening for a histological cell phenotype (acetylated α-tubulin) subsequently validated for a cell function (intracellular trafficking).
This unexpected discovery demonstrates a role for immune cell cytokines in epithelial cell fate and function, and adds an unexpected tier of complexity to the previously held paradigm that steroid and peptide hormones are the primary regulators of mammary gland development.
We have demonstrated that the discovery of a new territory, a sugary food source, a prey or an alien ant triggers a peculiar behavior in Oecophylla workers that first rub the underside of their mandibles onto the substrate, and then tilt their head to rub the upper side as well.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com