There was a significant association between bulbar onset symptoms and basal forebrain/hypothalamic pathology (Χ = 4.04, p = 0.044) with 71.4% of all patients having bulbar symptoms at disease onset demonstrating this pathology (compared to 28.6% of patients without bulbar symptoms at onset).
Therefore, despite the sample being arguably the largest to investigate WMH and cognition in persons in their mid−40 s, even larger samples are required to enable detailed evaluation of the small group of individuals who demonstrate significant pathology in this age group.
Although no pathological process involving the renal arterioles could be demonstrated on pathology, this may be ascribed to a sampling bias given the focal distribution of the renal perfusion defects.
That the injured eye, known as the exciting eye, and the contralateral eye, or sympathizing eye, demonstrate similar pathology suggests involvement of an autoimmune response.
Although the diagnosis of constrictive pericarditis is still challenging, a multimodality imaging approach can demonstrate pericardial pathology in detail and help us make a more accurate diagnosis and decide the optimal treatment option for patients with constrictive pericarditis.
Zebrafish have been evaluated as a model for E. ictaluri pathogenesis [29], and demonstrate characteristic pathology.
The use of real subjects to demonstrate acute pathology should aid the education of health care professionals.
It is also important to identify whether dogs with extreme scores on any subscale demonstrate behavioural pathology as well as how well owner report (like parent report) accurately reflects behaviour; however, those questions are beyond the scope of this study.
As previously reported, Dysf−/− mice demonstrate mild pathology at young ages seen primarily in small numbers of centrally nucleated fibers and isolated necrotic fibers.
However, some patients with ANCA-positive disease have been shown to demonstrate atypical pathology such as interstitial nephritis with vasa recta vasculitis in the absence of glomerulonephritis [ 79].
