Despite these limitations, utility of the simple bacterial expression systems has been appreciated for their ability to demonstrate the inherent predisposition of other mutant enzymes such as phenylalanine hydroxylase towards aberrant folding and mis-assembly [ Waters, 2003].
This is useful in demonstrating the genetic predisposition to emphysema, which probably would not have manifested to such degree without smoking.
31 The results demonstrate the existence of an association between telomere length and CRC predisposition, but show that this association is more complex than previously suspected.
These studies demonstrate the relevance of the TNC and COL5A1 gene polymorphisms in genetic predisposition to Achilles tendinopathy.
We demonstrate the potential importance of the homozygous risk allele to breast cancer predisposition in the Saudi population.
Our study demonstrates that the predispositions for many BRCAx familial breast cancer families can lie in each disease family.
Wnt7a heterozygous mice showed an increased sensitivity to Aroclor 1254, demonstrating the potential for genetic predisposition to endocrine disruption.
Other mouse models of spontaneous OS demonstrate a predisposition to OS development in the mandible [18], [19].
The distinct HIF and hypoxia dependence of miR-210 coupled with the hypoxia-independent genetic (ISCU mut/mut) predisposition to PH demonstrates the wide spectrum of human PH subtypes where control of Fe-S integrity controls pathogenesis, encompassing at least Group 1 PAH (HIF dependent), Group 3 PH (hypoxia dependent), and likely Group 5 PH ("metabolic" dysfunction) (Simonneau et al, 2013).
Our results also demonstrate that predisposition to CAP is strongly attributed to the effects of a number of genes with low penetrance and therefore imply that inter-locus interactions may be regarded as an important component of polygenic and multifactorial factors of susceptibility to CAP.
For the past ten years several association studies have demonstrated the importance of R alleles on melanoma predisposition [ 28, 29, 42, 56, 57].
