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In this study, we demonstrate the functional role of deregulated miRNAs in ACC cells using experimental cell culture systems.
To demonstrate the functional role of models within biology, we now present a contextualized argument using Listeria monocytogenes as a multipurpose specific model.
To demonstrate the functional role of activated neutrophils-induced CAF differentiation of normal MSCs, the supernatants from activated neutrophils-primed MSCs were collected and used for cell migration assay.
To demonstrate the functional role of MS/DB in the frequency control of the sniffing theta coherence, we performed unilateral muscimol microinfusions to attenuate septal activity pharmacologically (Shirvalkar et al., 2010; Brandon et al., 2011).
We infer distinct biological functions compared to Type III EMT, demonstrate re-routing of the TNF pathway and experimentally demonstrate the functional role of NF-κB activation in Type II EMT.
Autophagy induction was previously documented in involuting bovine mammary glands, but our studies are the first to demonstrate the functional role of ATG proteins in mammary involution using transgenic mouse models.
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Although many studies have demonstrated the functional role of AdipoR1 in mediating metabolic effects of gAd [10], [43], the role of this receptor in mediating the anti-apoptotic effects of gAd in cardiomyocytes remained to be estabished.
The study presented here has identified six genes encoding putative AQP membrane transporters in Ae. aegypti and demonstrated the functional role of three of them in regulation of water transport.
Our observation that fibrin formation was abrogated in the presence of supraphysiological concentrations of annexin A5 [28], [28], demonstrates the functional role of coagulation factor interactions with exposed PS during thrombus formation.
Silencing of Fas/CD95 by RNA interference, transfection with a FADD dominant-negative mutant that blocks Fas/CD95 signaling, and specific inhibition of caspase-8 prevented the apoptotic response triggered by edelfosine, hence demonstrating the functional role of DISC in drug-induced apoptosis.
Through in planta expression of candidate effectors, we demonstrated the functional role of one effector.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com