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Our findings demonstrate the engagement of unique regulatory modules in niche adaptation, implicate a critical role for bacterial genetic heterogeneity that surpasses transcriptional in vivo adaptation, and portray the dynamics underlying the selection of hypervirulent covS mutants over their parental WT cells.
However, only indirect evidence, obtained via invasive, destructive methods, exists to demonstrate the engagement of HDAC targets in brain.
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Previous studies have demonstrated the engagement of the PHC in the processing of episodic memory26 and emotional stimuli27.
Indirect support for this idea comes from other studies which have, for instance, demonstrated the engagement of the PCC when viewing social interactions between real people relative to identical scenarios performed by animated agents [11] as well as when participants played interactive games against human partners relative to computer partners [12].
Using this behavioural approach, we have demonstrated the engagement of different territories of the striatum during the transition from goal-directed to habitual drug seeking.
Here we extend these previous data demonstrating the engagement of these activation/deactivation mechanisms during search and detection in complex naturalistic scenes.
We demonstrate the three-dimensional engagement of the apex region of the CDRH3 with the conglomerate of gp41 epitope and membrane lipids as a means of effective binding and neutralization of the virus.
In the Vestibule at the top of a branching staircase, cabinets are filled with curiosities from around the globe that demonstrate the Oneidans' Victorian engagement with the wonders of the outside world: a brass Chinese compass, an emu egg from Australia, a lamp from Pompeii, a mastodon jaw.
Among the top 10 YouTube partners, VEVO demonstrated the highest engagement (62 minutes per viewer) and highest number of videos viewed (696 million), while Machinima exhibited the second highest engagement (60 minutes per viewer) and number of videos viewed (347 million).
Thus, these data demonstrate that the engagement of α5β1 integrin and GSK3β activation both support resistance to extrinsic and intrinsic pro-apoptotic pathways of serum-starved adherent leukemic cells.
Using functional assays of bacterial adhesion and internalisation, microscopic analysis, and a panel of CEACAM1 deletion mutants we demonstrate that the engagement of CEACAM1 by non-opaque meningococci occurs in a manner distinct from Opa protein-mediated association.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com