In addition, these studies also demonstrate that this continuum of bioassays (representing different levels of complexity) provides an effective means of evaluating other candidate compounds that target specific components of the Ca2+ regulatory machinery and that therefore might be beneficial in the treatment of AD.
Collectively, these findings demonstrate that the pirfenidone treatment benefit is observed across the continuum of baseline disease severity and subsequent rates of FVC progression.
We employ finite-element simulations within continuum elasticity theory to demonstrate that the observed deformation of the tube walls is the result of elastic strain energy relaxation induced by the nucleation of noble metal clusters on the graphene lattice.
But modern references abound, in the form of numerous pieces from Kartell, ingeniously placed throughout the house, which demonstrate that the present is just the latest point on a continuum.
Most importantly, however, they demonstrate that the increase in prefrontal noradrenergic release induced by both rewarding and aversive natural stimuli can be graduated on a continuum by varying the salience of stimuli.
Several lines of evidence demonstrate that the transition between PV, ET, and PMF is frequent in JAK2V617F-positive Ph− MPN patients, suggesting for these disease entities a biologic continuum [ 6].
It has also been used to monitor the deformation of graphene and to demonstrate that continuum mechanics is still valid even for a one-atom thick material.
Extending their application to clinical populations as in this study represents an important step in demonstrating that similar processes can help account for individual differences across the continuum from healthy functioning to clinical symptoms.
This was to be achieved by setting forth a number of "first principles" concerning the continuum akin to the axioms and postulates of Euclid's Elements and then demonstrating that the further assumption that a continuum is composed of indivisibles leads to absurdities (see Murdoch [1957]).
Watkins and Makin (1996) have demonstrated that the ratio of the spectral contrast over the target continuum to that of the precursor continuum has a strong influence on the size of the categorization shifts.
