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Our results demonstrate that the altered gene in mapped mutants can often be revealed through genetic complementation tests with mutants disrupted in cloned genes localized to similar chromosomal regions.
Mechanistically, we used the clock-driven rhythms in bioluminescence to demonstrate that the altered feeding time not only shifted the peripheral clocks in the liver, but also altered the circadian clock in the hippocampus.
We demonstrate that the altered sequence did not affect IND1 mRNA stability, yet it led to a decrease in Ind1 protein level.
These results clearly demonstrate that the altered thymic structure associated with aging is neither necessary nor sufficient for thymic involution, with premature thymic involution in FVB/N mice being controlled by hematopoietic factors.
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Furthermore, we have demonstrated that the altered mitochondrial dependencies following inhibition of the dominant TK extend beyond mitochondrial carbon flux and respiration.
The study by Rau et al. [ 37] demonstrated that the altered processing of miR-1, consequent to insufficient availability of MBNL1, is linked to heart defects in DM1 patients and also provided a mechanistic explanation for this observation.
In contrast, HCVpp failed to infect 293-T cells expressing group III claudin-1 mutants, demonstrating that the altered claudin-1-CD81 interaction does not support HCV entry (Table 1).
Results demonstrate that the significantly altered green space pattern could be quantified using landscape metrics in each local area.
The research is "excellent work" demonstrating that leptin can alter the brain's wiring diagram, says endocrinologist Jeffrey Flier of Harvard Medical School.
These pictures demonstrate that the treatment alters both the morphology and the dispersion (dimensions of the powder particles' peak cross section for this fraction (d)).
The results demonstrate that Glu altered the astrocyte morphology under normoxia, compared with the control (no Glu).
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