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These data demonstrate that altering the timing of critical weight, by exogenous ecdysone administration, impacts final adult size.
We demonstrate that altering the chemistry of the MDP sequence changes SHED response to the encapsulating hydrogel.
These results demonstrate that altering the size and timing of critical weight, by manipulating expression of FoxO and Usp, has definitive effects on final adult body size.
These data demonstrate that altering the cleavage status of PINK1 induces significant changes in the ΔΨm, and that reduced cleavage of PINK1 is associated with low basal Δψm.
These results further support the notion that variants that influence cell-type-specific gene regulation are major contributors to common disease risk, and extend this concept to demonstrate that altering the expression of genes under exquisite regulation can frequently lead to increased risk.
By transfecting such variants with expression vectors encoding various different heavy chains, Radic and colleagues [ 19], Katz and colleagues [ 20], and Pewzner-Jung and colleagues [ 28] were all able to demonstrate that altering the numbers of arginines in CDRs of the heavy chains altered the ability of murine monoclonal antibodies to bind DNA.
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This work demonstrates that altering the genetic code broadly obstructs the propagation of horizontally transferred genetic elements and supports the use of genomic recoding as a strategy to stabilize engineered biological systems.
These findings are in agreement with a recent study demonstrating that altering the level of VpreB2 expression impairs early B cell development [66].
Swanson et al [12] recently demonstrated that altering the RNA nuclear export element used by HIV-1 gag-pol mRNA from the RRE to the CTE resulted in efficient trafficking and assembly of Gag at cellular membranes in murine cells, which are notable for their inability to support HIV-1 assembly and budding [12], [15], [16].
Our computational results demonstrated that altering the strength of TGF-β1 altered LV remodeling outcomes.
We also demonstrated that altering the stiffness of Dynesys system spacers can alleviate stress on the adjacent level during extension of the intact spine.
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