Osteoprotegerin, and antibodies directed to the ligand or the receptor activator of nuclear factor-κB, have demonstrated substantial activity in inhibiting osteoclast activation, recruitment and differentiation.
High-dose intravenous cisplatin demonstrates substantial activity against malignant gliomas recurrent after chloroethylnitrosourea (CENU) failure.
Second, oxaliplatin consistently demonstrates substantial activity against a variety of CDDP-resistant tumours (Cvitkovic, 1998; Raymond et al, 1998).
Ifosfamide, an oxazophosphorine alkylating agent like cyclophosphamide, has demonstrated substantial activity in advanced breast cancer (Ahmann et al, 1974).
It is important to note that CYT387 is the first JAK inhibitor demonstrating substantial activity against MF-associated anemia and that anemia is the chief determinant of quality of life in MF and is also the most important prognostic factor for survival.
nab-Paclitaxel 300 mg/m q3w demonstrated substantial antitumor activity with a manageable safety profile in this patient population.
Sunitinib 37.5 mg on a CDD schedule in combination with trastuzumab (weekly or 3-weekly) demonstrated substantial antitumor activity in patients with ABC, with an ORR of 37% and a CBR of 56%.
Large-scale cDNA collections (e.g., Carninci et al. 2005), genome-wide tiling array experiments (Johnson et al. 2005), and whole transcriptome shotgun sequencing (RNA-seq) experiments (Cloonan et al. 2008; Guttman et al. 2010; Cabili et al. 2011) have demonstrated substantial transcriptional activity emanating from sequence lying between protein-coding genes in mammalian genomes.
Our exposure models combined ambient dispersion and activity-based estimates that demonstrate substantial nonoccupational asbestos exposures for residents of this neighborhood, albeit with considerable variability by exposure pathway (Adgate et al. 2011).
Despite this, the findings did demonstrate substantial variety in research variables and instruments and unlike many other overviews of research activities, the current study did not overlook smaller projects.
Reserves often demonstrate substantial financial returns from tourism related revenue streams, and provide enhanced opportunities for community education and recreational activities".
