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We demonstrate responses to a small panel of ligands and examine the importance of AR expression level, the link between AR nuclear patterning and transcriptional reporter gene activity, the relationship between observed responses and cell cycle, and the functional impact of the LNCaP T877A and AIS F764L mutations.
The general trends demonstrate responses producing decreased underfoot pressure at the site of stimulation.
This recent work puts into perspective the magnitude of the problem and naïvety of the expectation that any single agent can routinely demonstrate responses in early clinical trials.
Illustrative quotes from adolescents selected to demonstrate responses which were common, contrasting or representing a summary of a topic, are provided in below with assignment of IDs and adolescent sex and year level.
Although pancreatic fat content was 30% higher in the diabetic group, the study was powered to demonstrate responses to the dietary intervention rather than to test differences from weight-matched non-diabetic individuals.
These cells express functional wild-type EGFR [ 35], demonstrate responses to hypoxia through HIF-1 and HIF-2 regulation [ 10], and are frequently used as an in vitro model of CRC [ 36].
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Park et al. demonstrated responses of rat MSCs on vertically-oriented and highly-ordered TiO2 nanotubes.
The humidity response of the sensor constructed using ZnS spheres demonstrated responses of 2.3 to 24.7 for 33% RH to 95% RH.
In contrast, primary cultures of human aortic endothelial cells (HAEC) demonstrated responses to a broad range of PAMPs.
Numerous studies have demonstrated responses to acyl HSLs, including apoptotic and inflammatory signaling, in a range of host cells.
A Phase I/II trial demonstrated responses in soft tissue, visceral disease, and bone metastases in CRPC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com