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Prospective trials of this agent demonstrate response rates of 60 to 80percentt in previously treated disease [ 9– 14] including patients who are refractory to rituximab.
We postulated that inability to demonstrate response in non-BRCA carriers in which BRCA is inactivated by other mechanisms or with deficiency in homologous recombination for DNA repair is due to lack of molecular markers that define a responding subpopulation.
The study utilized an optimal two-stage design (Simon, 1989); the first 19 evaluable patients had to demonstrate response to treatment in at least five patients before the second stage could proceed to enter the remaining patients.
However, only continuously applied low dose oral etoposide, paclitaxel, gemcitabine, and, most recently, oxaliplatin have thus far been able to demonstrate response rates of about 13 20% in patients with cisplatin-refractory germ cell cancer (Miller and Einhorn, 1990; Motzer et al, 1994; Bokemeyer et al, 1996, 1999; Einhorn et al, 1999; Kollmannsberger et al, 2001).
As the paradigm of patient selection for AD-modifying candidate therapies shifts to an enrichment of the MCI population, drug developers work to reduce costs of clinical trials by aiming to demonstrate response over a shorter duration and with fewer numbers of subjects.
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The general trends demonstrate responses producing decreased underfoot pressure at the site of stimulation.
Table 3 demonstrates response to IC and hypofractionated concurrent chemoradiation.
None of the non-trappers demonstrated response to treatment.
PLD has demonstrated response activity even after prior anthracycline exposure.
Seventy-four patients who demonstrated response went on to have radical radiotherapy; 4 opted for cystectomy.
TMZ was administered to patients who demonstrated response to it during the treatment at diagnoses.
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