To our knowledge, the current study is the first to demonstrate recognition of NY-ESO-1 by tumor-infiltrating and tumor-associated (i.e., ascites derived) T cells, as evidenced by the results for patient IROC013.
Although this assay has not been validated as a correlate of protection, this trial demonstrates that the standardised assay is able to demonstrate recognition of the native protein and thus functionality in vitro.
We employed a cross-modal matching task in order to allow patients to demonstrate recognition of voices and faces using an alternative procedure that did not rely on word retrieval.
To improve motivation and thereby increase staff performance, attention should be given to motivating factors, for example by increasing the individual's sense of achievement and to demonstrate recognition of that achievement.
Thus, our approach is unique, as we utilize short RNA subtraction and assembly in mammalian-derived cells, to maximize pathogen-to-host-ratio; demonstrate recognition of both viral and bacterial infecting agents; and suggest a possible siRNA-related immune response.
