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The prediction by the fatty acid model of attention-deficit hyperactivity disorder [ 37] that there might be an increase in cerebral phospholipid breakdown in this disorder was difficult to test directly using magnetic resonance spectroscopy, but a breath test investigation did indeed demonstrate raised levels of ethane in such children [ 17].
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It has, however, also been demonstrated that raised levels of insulin-like growth factor 1 are associated with increased risk of different cancers (Gunnell et al, 2001).
The reduced responsiveness of cells from M. tuberculosis-infected individuals with advanced disease is in line with previous reports which demonstrate raised endogenous levels of IL-8 and reduced Mycobacterium-stimulated IL8 in patients with advanced leprosy disease [ 38].
In addition to mitochondrial dysfunction, we also demonstrate that loss of PLA2G6 activity is associated with raised levels of reactive oxygen species.
We demonstrate that oestradiol supplementation results in markedly enhanced tumour regression and that this is associated with raised levels of intratumoral IFN- γ.
Pioglitazone and rosiglitazone unaltered and raised levels of GFAP, respectively.
Raised levels of distress can have detrimental effects.
HFpEF additionally featured raised levels of peripheral oedema.
Previous studies have demonstrated raised serum levels of matrix metalloproteinase 9 (sMMP-9) in a range of cancers.
Previously, Bresnihan and colleagues [ 11] demonstrated raised serum levels of IL-18 and its binding protein in RA patients compared to psoriatic arthritis patients, but this did not seem to correlate with response to therapy with methotrexate, whereas CRP levels did.
They also raise levels of high-density lipoprotein (good cholesterol).
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