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They demonstrate potent in vitro and in vivo fungicidal activity against Candida species [39].
The compounds demonstrate potent inhibition against Pim-1 and Pim-2 in enzyme assays.
We report a series of tubulin targeting agents, some of which demonstrate potent antiproliferative activities.
The 2-benzoylpyridine thiosemicarbazone (BpT) chelators demonstrate potent anti-proliferative effects against tumor cells.
Herein we disclose the identification and optimization of novel heterobicyclic inhibitors of TGFβRI that demonstrate potent inhibition of SMAD phosphorylation.
Analogs in this series demonstrate potent agonist activity as measured by in vitro and in vivo assays for CCK1 agonism.
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All the tested compounds demonstrated potent cytotoxicity against HCT 116.
Compound 8b demonstrated potent antinociceptive activity in vivo.
The MTT assays demonstrated potent cytotoxic activity against HepG2 cells.
Some of amidrazone-containing hetererocycles have demonstrated potent activity in vitro as antimicrobial agents.
Compounds that inhibit the IN enzyme have demonstrated potent anti-HIV activity [12].
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