Sentence examples for demonstrate mutation from inspiring English sources

We also demonstrate mutation discovery from a colorectal cancer tumor sample matched with normal tissue.

For example, pGBM demonstrate mutation of the PTEN gene and frequent loss of heterozygosity on chromosome 10q (inclusive of the PTEN gene locus), amplification of EGFR, deletions of CDKN2A (p16), while sGBM and their lower grade precursor lesions have frequent mutations of the TP53 gene and the IDH1 gene [ 3- 7].

Vaccine viruses were safe at all doses tested and did not demonstrate mutations associated with a reversion to virulence when serially passaged in mice.

Notably, many cancers that do not demonstrate mutations in any TGF-β signaling cascade members show down-regulated levels of TFGBR2, demonstrating the oncogenic potential of TGF-β.

The possibility therefore remains that tumor samples at primary or metastatic sites might demonstrate mutations that do not appear in circulating nucleic acid.

Moreover, recombinant cytokines may offer novel treatment approaches for individuals found to demonstrate mutations in genes responsible for the production of cytokines.

Mutational analysis of 10 MSI-H multiple cancers that expressed MLH1, MSH2 and MSH6 failed to demonstrate mutations in the MLH1 or MSH2 genes.

Out of 29 patients, 19 showed mutations in both the alleles, whereas seven patients demonstrated mutation in one allele.

Explanations based on constraints begin by demonstrating mutation rates, path-dependence, or other constraints that limit optimality.

In addition, these samples had been assessed for IDH1 and IDH2 mutation status, 14 out of 20 (70%) samples demonstrated mutation in the IDH1 R132 codon.

Breast cancer subgroup analysis demonstrated mutation of at least one of the three genes with the highest frequency in HR+/ERBB2- tumors (133/289; 46.0%).