Sentence examples for demonstrate its involvement from inspiring English sources

Here, we report on the identification of SMPDL3B as a lipid-modifying enzyme and demonstrate its involvement in the regulation of TLR-induced signaling processes.

Collectively, our SILAC analyses of the KSR1-regulated phosphoproteome profile in cancer cells demonstrate its involvement in multiple biological and molecular processes as well as intricate signalling pathways.

Our data suggest that STATIP1 may be a negative regulator of STAT3 and demonstrate its involvement in IM therapy resistance in CML.

The role of c-Myc as a transcriptional repressor of miR-16 has previously been shown [ 36, 73] and we here also demonstrate its involvement in mR-16 downregulation upon progestin treatment.

Keeping in mind the few observations that the calmodulin level is significantly higher in lung cancers and its level correlates with the hystopathological grading and tumor staging, we inhibited Ca2+/calmodulin signaling and were able to demonstrate its involvement in the stability of c-FLIPS protein and survival of NSCLC cells in response to TRAIL administration.

As investigations into other cell adhesion molecules have revealed numerous important functions in animal development (Thiery, 2003; Halbleib and Nelson, 2006), LINKIN's expression in many human and C. elegans tissues suggests that future studies will demonstrate its involvement in many processes.

Although the hippocampus is not commonly thought to be involved in addictive behaviors, recent evidence demonstrates its involvement in psychostimulant responses and addiction.

rufipes, the determination of the role of this species in malaria transmission needs further investigation to incriminate it, as a recent study conducted in Burkina Faso has demonstrated its involvement in the transmission of human Plasmodium [ 30].

Earl W. Sutherland, Jr., in full Earl Wilbur Sutherland, Jr. (born Nov. 19, 1915, Burlingame, Kan., U.S. died March 9 , 1974 Miami, Fla ., American pharmacologist and physiologist who was awarded the 1971 Nobel Prize for Physiology or Medicine for isolating cyclic adenosine monophosphate (cyclic AMP) and demonstrating its involvement in numerous metabolic processes that occur in animals.

Consistently, WUS is a direct activator of the floral patterning gene AGAMOUS [25], demonstrating its involvement in both proliferation and differentiation.

VEGFR1 was previously thought to be a non-signaling "decoy" receptor, but recent studies have demonstrated its involvement in pathologic angiogenesis [7] and the recruitment of BMDCs [8], including macrophages and endothelial precursor cells [9].