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The first two outcomes were used to demonstrate the clinical benefits of amoxicillin for patients with an acute uncomplicated LRTI in primary care, with the third used to demonstrate harms.
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Wright and Manne are quite explicit -- they are not concerned with manipulation unless one can clearly demonstrate harm to consumers.
It is sometimes sufficient to demonstrate harm to the competitive process, especially if it can be shown that this harm is the result of a deliberate attempt to achieve monopoly power.
King did not respond to the letter, but his response to the appeal -- which began "Dear Brother Waun" -- categorically dismissed his grievance: "The Appellant cannot demonstrate harm to himself or any other member of our union".
Why then did the OSCILLATE trial demonstrate harm with HFOV?
It is the first study to demonstrate harm related to provision of exogenous glutamine in critically ill patients.
Our finding of an association between compulsory drug detention experience and drug planting by police builds on a substantial body of literature demonstrating harms from and police corruption associated with drug enforcement policing [ 27, 28], and raises concerns about the tactics used to force drug users into compulsory drug detention settings.
The AAFP/US Preventive Services Task Force guidelines do caution PCPs that SSRIs, and fluoxetine, in particular, have "demonstrated harms" in the "risk of suicidality" in children, and that there is insufficient evidence to recommend psychotherapy, combination fluoxetine plus psychotherapy, or routine screening for depression in children.
In short, the game is over before it begins if your opponent can be counted on to say that either there is no demonstrated harm or, no matter how much harm there may be, it will not be enough to justify restrictions on speech.
When Glinsmann and his F.D.A. co-authors decided no conclusive evidence demonstrated harm at the levels of sugar then being consumed, they estimated those levels at 40 pounds per person per year beyond what we might get naturally in fruits and vegetables — 40 pounds per person per year of "added sugars" as nutritionists now call them.
Ricroch et al.[1] present a qualitative methodological critique of our study demonstrating harm from MON810 on D. magna.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com