Sentence examples for demonstrate firstly that from inspiring English sources

The results reported here demonstrate, firstly, that wavelet analysis is applicable to those systems in which FFT techniques also work.

The objective of this study was to advance this encouraging in vitro work to towards clinical translation, by undertaking a preliminary in vivo study to demonstrate, firstly, that PLGA microspheres could be delivered to the disc and retained for a clinically relevant time frame in vivo; and, secondly, that IL-1ra delivered from these microspheres maintained bioactivity in the in vivo space.

These results demonstrate firstly that the two amino acids R146 and R280 are required for recombination catalysis, and that the reaction observed with wild type IntI1 was due to the intrinsic catalytic capability of the recombinant integrase.

Collectively, our data demonstrate firstly that WTD exerts antinociceptive activity in inflammatory conditions by attenuating mechanical, cold, and heat hypersensitivities.

Our main results demonstrate, firstly, that the PtiO2 data measured in uninjured areas of brain tissue of severe TBI patients increases with higher CPP.

These results demonstrate firstly that MreB protofilament formation is essential for cell shape maintenance and secondly that these protofilaments need to interact with their flat sides to make functional MreB filaments.

In a landmark paper, Kamada et al. demonstrated firstly, that Atg1 kinase activity is strongly enhanced during starvation; secondly, that both Atg13 and Atg17 are essential for this activity; and thirdly; that both starvation and rapamycin treatment leads to a considerable dephosphorylation of Atg13, which subsequently results in an enhanced affinity for Atg1 [ 9].

Our research demonstrated firstly that the natural phytoestrogen genistein can alleviate the deleterious effect of the most commonly used plasticizer DEHP when administrated prepubertally.

When we studied the regulation of Ank expression by TGF-β1, we demonstrated firstly that ERK 1/2 and p38-MAPKs were activated in our cell culture system.

Our data demonstrated firstly that this signaling pathway is activated by APAP in hepatocytes and secondly that PTP1B deficiency mimics the inhibition of GSK3 β or SKF on the downstream mediators of this pathway.

Our analysis demonstrates, firstly that micrometastases can be clearly identified in histologically node-negative patients with vulval cancer and, secondly and more importantly, that women with micrometastases are at a significantly increased risk of recurrence.