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Unlike the control shRNA MCF7S cells, the shERα clones demonstrated diminished response to ICI, as the compound had no significant effect on cell number (Figure 9A).
Schenarts and colleagues [ 33], in a RCT including 18 patients requiring intubation in the emergency department, used etomidate as the induction agent in 8 patients (n = 8) and demonstrated AI (defined as diminished response to a CST of 250 μg of cosyntropin at 4 hours) that resolved by 12 hours; the other 10 patients were induced with midazolam and did not show AI.
The role of NADPH oxidase in ROS production in neurons was demonstrated by using neurons from p47phox-deficient mice, which showed diminished response to ROS production in response to excitotoxic agents (Brennan et al., 2009).
They further showed that loss of both populations led to a diminished response to the drug and enhanced tumor progression.
The apparently attenuated response to α1-adrenergic agonists in vivo may reflect diminished response to these normally synergistic vasopressor pathways.
This diminished response to IV adenovirus delivery was not an exclusive property of the Ad-OVA.
The exo hypocotyls showed a diminished response to BL.
Aging is characterized by a diminished response to stress [ 32].
This diminished response to the anorexigenic effects of leptin is referred to as "leptin resistance".
A few studies have suggested diminished response to treatment in older patients with adductor spasmodic dysphonia.
In vivo, this phenomenon is related to a decreased febrile response and to a diminished response to subsequent severe infection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com