Sentence examples for demonstrate defective from inspiring English sources
We previously reported that Rhoh-/ T cells demonstrate defective CD3ζ phosphorylation and ZAP-70 recruitment to the TCR complex which results in the impaired TCR signaling and T cell development[3].
We could also demonstrate defective mycobacterial association with Clecsf8−/− thioglycollate-elicited macrophages and neutrophils in vitro.
Without SCFβTrCP, T cells demonstrate defective IκBα degradation and reduced NFκB activation [ 14].
Patients with SLE demonstrate defective clearance of apoptotic cells, which evokes a secondary transition into necrotic cell death [ 10].
Recently, it has been proposed that B cells are involved in the early innate immune response during experimental bacterial sepsis [ 101] and Darton et al. reported that adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B-cell activation [ 106].
In the liver, there was a concomitant reduced expression of glucose-6-phosphatase mRNA and glucose production from pyruvate (pyruvate tolerance test), demonstrating defective hepatic gluconeogenesis as a cause for the T. cruzi-induced hypoglycemia, despite reduced insulin, but elevated glucagon levels.
One-hundred-sixty single-fiber EMG studies of the extensor digitorum communis muscle were performed on 127 patients with myasthenia gravis; 131 demonstrated defective neuromuscular transmission.
Using gene-targeted mice deficient in RhoH, we have previously demonstrated defective thymocyte development, positive and negative selection and TCR signaling.
Two ACE chimeras were generated by substituting regions of the C domain with corresponding N domain sequences which also demonstrated defective intracellular processing, were enzymatically inactive, and did not localize to the cell surface [42].
Mcm2-7 was initially identified during a genetic screen for S. cerevisiae mutants that demonstrated defective plasmid segregation (minichromosome maintenance [ 12]).
For example, the fact that 18% of patients waited more than an hour before mammography and ultrasound demonstrated defective organization.
