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Our findings demonstrate a reduced functional connectivity within the prefrontal and temporal cortices of the DMN in patients with MwoA during the interictal period.
Altogether, our observations demonstrate a reduced electron transport in some inherited PH/PGL and suggest that activation of the hypoxic response may be directly involved in the decreased mitochondrial respiration in these tumors.
According to the biphasic model, a S611D construct should shut down the uptake ability of the transporter while the DD construct should demonstrate a reduced or eliminated 5HT uptake capacity due to its intracellular localization.
In a human esophageal squamous cell carcinoma xenograft model or in a syngenic murine model of mammary gland tumorigenesis, tumor cells overexpressing Csta demonstrate a reduced capacity to form lung or bone metastasis respectively, suggesting that Cystatin A may act as a tumor suppressor within these contexts [15], [16].
Animal data demonstrate a reduced risk for death with fluid resuscitation in severe hemorrhage.
13 However, others found that NK cells retrieved from the intrahepatic compartment demonstrate a reduced cytotoxic function ex vivo.
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Kinetic studies of GKRP-P446L have demonstrated a reduced ability of this variant protein to inhibit GK as a consequence of reduced responsiveness to F6P, and cellular studies have shown impaired GK binding and nuclear storage [ 28, 30, 31].
And though much more research is needed to ascertain the functional consequences of these brain changes, in some tests, heavy users demonstrated a reduced ability to solve complex problems on intelligence tests and showed signs of short-term memory loss.
Three recently completed randomized-controlled trials have confirmed the protective effect of male circumcision demonstrating a reduced risk of HIV acquisition between 48 60%.
The efficient and specific deletion of exon E1 of PPR in T cells was established by demonstrating a reduced exon 1-containig PPR mRNA expression in T cells from PPRT cells −/− mice.
However, these findings are not in line with data presented by Ashrafi et al. (2003) demonstrating a reduced fat content in pept-1 RNAi treated worms, but discrepancies between knockout and RNAi knockdown phenotype were reported for other genes before.
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CEO of Professional Science Editing for Scientists @ prosciediting.com