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Our data also demonstrate a positive feedback loop between regulation of UCH L1 and β-catenin indicating that UCH L1 affects this major oncogenic pathway [35].
Here we demonstrate a positive feedback between UCH L1 and oncogenic β-catenin/TCF signaling, providing evidence that in transformed cells UCH L1 up-regulates its own expression through β-catenin/TCF-dependent transcription.
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When CD40 was engaged for 20 hrs, both populations from NOD, BALB/c, and NOR mice induced an increase in CD40 expression demonstrating a positive feedback loop.
Interestingly, a recent study demonstrated a positive feedback loop in which CRAF phosphorylation is dependent on MEK activity 21.
Our previous study demonstrated a positive feedback loop between RAGE and NF- κB during oxidative stress in pancreatic tumor cells exposed to chemotherapy.
The observed regulation of S100A8 by AR-ERK signaling is in agreement with a previous study that demonstrated a positive feedback loop between Ras-activated ERK and S100A8 expression [ 48].
In addition, our study demonstrated a positive feedback loop that enable the creation of "space" for growing tumors: this is achieved via active release of exosomes, leading to a continual release of exogenous matrix metalloproteinases, such as MMP-1.
Thus, the direct link between miR-19a/b miRNAs and the c-Myc antagonist gene MXD1 demonstrated a positive feedback loop between c-Myc, miR-19a/b and MXD1 that may be useful in reducing the opposite effects.
Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 viactivationof of PI3K/AKT/HIF-1α pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.
You can demonstrate a positive ROI.
Our results demonstrate that such a positive feedback loop which involves the control of translation through polyadenylation can indeed be bistable over a wide range of parameters.
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