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These results demonstrate a function of USP13 in ERAD downstream of retrotranslocation and suggest a potential functional interplay between USP13 and Bag6 that is required to maintain retrotranslocated substrates in a soluble and degradable state.
To demonstrate a function of Tin2 in the plant cytosol, we expressed tin2 without its secretion signal under the CaMV 35S promoter in maize leaf epidermal cells after biolistic bombardment.
A hydrophobic pocket at the inside of the concave surface is open in the presence of an internal peptide ligand and closes in the absence of this ligand, and we demonstrate a function of this pocket in the inhibition of ASIC3 activity.
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In vitro studies of the past decade have demonstrated a function of ZO-1 in organisation of confluent cell layers.
This is the first report to demonstrate a pathological function of loss of H4K20me3 in cell invasion, which could promote metastasis in vivo.
Our results demonstrate a general function of Egr-2 in regulation of lymphocyte development, suggesting that Egr-2 expressed in restricted stages of lymphocyte development plays a dynamic role for the regulation of progenitors and the maturation of lymphocytes.
Taken together, we present a regulatory framework of TFs that establish, expand, and restrict RSC features in the post-embryonic retina and demonstrate a crucial function of Rx2 in the definition of retinal stem cell types.
These data demonstrate a novel function of APC beyond cell cycle control and implicate critical role of ubiquitin-mediated proteolysis in ciliary disassembly.
Therefore, our data demonstrate a novel function of Siglecg in regulating postnatal expansion of the B1a compartment.
We demonstrate a novel function of CD46 in terminating T cell activation.
Here, we demonstrate a critical function of interleukin-32β (IL-32β) in vascular inflammation.
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