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Sedentary mdx mice, although run for a shorter distance than wild type [14], maintain the same exercise performance over time, whilst the exercised mdx demonstrate a dramatic increase in fatigability between the start and the fourth and fifth week of training (Fig. 6C).
These assays also demonstrate a dramatic increase in infectious virus release from CIITA-expressing cells as compared to cells expressing vector only (Figure 2A & S2), despite significantly fewer virus particles being released from a CIITA-expressing cell (as measured by pg/mL of p24 in the culture supernatant, Figure 2B & S2).
By using an antibody against GFAP, a marker for reactive gliosis in Müller cells, we could clearly demonstrate a dramatic increase in GFAP expression in β2−/−/γ3−/− mice (Fig. 1B') indicating that Müller cells were undergoing gliosis, a pathobiologic response, in β2−/−/γ3−/− retina.
Transmission electron microscopy and Oil-Red O staining further demonstrate a dramatic increase in lipid deposition in uterine epithelial cells upon DES exposure.
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We demonstrated a dramatic increase of adenoviral replication (up to 100-fold) in mouse cells via E1B-55K expression and subsequent viral spreading in mouse tissue.
Occupants of buildings have also recently demonstrated a dramatic increase in awareness regarding building operation, energy usage, and indoor air quality.
Analysis of the biophysical properties of the mutant channel demonstrated a dramatic increase in persistent sodium current, incomplete channel inactivation, and a depolarizing shift in the voltage dependence of steady-state fast inactivation.
Furthermore, C57BL/6J WT mice demonstrated a dramatic increase in level of global oxidative stress, evidenced by the increased uptake of DHE staining at 24 and 48 h following CLP while C57Bl/6 MCAT +/+ transgenic mice demonstrated a minimal increase in oxidative stress (Fig. 4a c).
It is worth noting that our study demonstrated a dramatic increase in genes associated with desmosome complex in Cr VI) transformed cells.
The same experiment, reproduced in thirteen WT mice, demonstrated a dramatic increase in rhythmicity following paxilline microinjection (Fig. 7E), mimicking the firing pattern of BK−/− mice illustrated in Fig. 2B, and a moderate increase in spike frequency (Fig. 7F).
Despite the fact that this same genotype repeatedly demonstrates a dramatic increase in climbing ability when exercised early in life (Fig. 2A), exercise-training later in life showed no discernible effect.
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