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Therefore, when considering the benefit of GM-CSF as an adjuvant it is crucial to consider the mode of GM-CSF delivery and demonstrate a clear benefit of inclusion.
Specifically, previous studies did not demonstrate a clear benefit of Medicaid managed care.
Previous studies did not demonstrate a clear benefit of Medicaid managed care [ 16, 20].
Studies also failed to demonstrate a clear benefit of metformin on microalbuminuria in diabetic patients (14).
It has been considered a promising agent [ 114] but clinical trials failed to demonstrate a clear benefit [ 118].
Although studies have failed to demonstrate a clear benefit of PAC use, neither have any corroborated the initial report of PAC-induced mortality.
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The randomized trial in advanced metastatic melanoma demonstrated a clear benefit with prolongation of survival.
In fact, the available data have not demonstrated a clear benefit of adjuvant chemotherapy.
Fluoridation demonstrated a clear benefit in terms of better oral health for young children.
The UK MRC OE02 trial demonstrated a clear benefit for neoadjuvant treatment (Medical Research Council Oesophageal Cancer Working Group, 2002).
Hyperoncotic albumin has demonstrated a clear benefit in patients with cirrhosis [ 8, 9].
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CEO of Professional Science Editing for Scientists @ prosciediting.com