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These cells typically also had a demonstrable response to BikBH3, suggesting a potential co-dependence on either Bcl-xL or Bcl-w, though this response was less robust (reduced compared to positive control release; p<0.05).
Given the number and variety of genes that we found to be differentially regulated, along with the indirect and relatively mild nature of exposures that culminated in demonstrable response differences in immunology, histopathology, clinical pathology, and lung function, the search for single candidate genes may need to evolve to an examination of global epigenetic alterations.
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The consistent association with sepsis, demonstrable dose-response relationship, and temporal progression in patients who develop sepsis make Angiopoietin-2 an attractive potential biomarker in sepsis.
An interesting question for the future will be, if vaccination can induce demonstrable CTL responses against CTAGs expressed in breast cancer, whom should be offered such vaccination?
We find that after a demonstrable initial behavioral response (consistent with social distancing) at the onset of the outbreak, there was attenuation in the response before the conclusion of the public health intervention.
Despite the inherent brittle nature of such materials, γ-TiAl typically exhibits considerable ductility at elevated temperatures and a demonstrable uniaxial creep response.
Bisno et al. found that, despite the development of demonstrable humoral immune response to M protein, acquired protective immunity did not occur.
The effects of somatostatin analogues are demonstrable as biochemical response rates (inhibition of hormone production) in 30 70% of patients and as symptomatic control in the majority of patients.
In conclusion, nasopharyngeal colonization in young children resulted in demonstrable serum IgG responses to pneumococcal capsules and surface/virulence proteins.
There was no demonstrable impairment in responses to PPSV-23; >2-fold increases were seen for ≥7 of 14 pneumococcal serotypes in 96.6% of UST-treated patients and 92.6% of controls.
The absolute CD4 count correlated with the likelihood of having demonstrable IFN-γ responses to each mycobacterial antigen: ESAT-6, Pearson r = 0.1076, P < 0.0001; Ag85 Pearson r = 0.0488, P < 0.0356; and WCL Pearson r = -0.0868, P = 0.0002.
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