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Although extracts of microbial agents can logically induce demonstrable production of interleukin-2, interferon, or activated immune cells, evidence of a clinical impact remains extremely limited.
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We focused on defining potential roles for serum CA19.9 at key clinical decision-making time points in patients who have demonstrable CA19.9 production.
By contrast, whilst TNFα expression is upregulated in degeneration, gene and protein expression of the predominant TNF receptor (TNF R1) is, if anything, reduced, with few cells showing demonstrable protein production.
However, as the 8 evaluated subjects were selected from a total of 16 based upon demonstrable virus production following 335nM vorinostat ex vivo stimulation, the effect on a non-selected study group may be of less magnitude.
Although no differences in total cellular cAMP levels were detectable, either biochemically or by FRET live-cell microscopy, a transient burst of cAMP production was demonstrable in the immediate vicinity of the forming phagosome.
Nevertheless, under all culture conditions tested for fetal human testis explants, no significant attenuation by MBP of testosterone production was demonstrable.
Relatively modest stimulatory effects of hCG and 22R-CHO on testosterone production were demonstrable, whereas KTZ caused marked suppression of testosterone production, in contrast to its ineffectiveness in the fetal rat testis cultures.
In no case was evidence of BhCG production demonstrated in these tumours despite its presence being demonstrable in positive controls.
There was a demonstrable increase in IFN-γ production after the third immunization in all vaccine groups.
In more experimentally amenable species it has been shown that there is a demonstrable energetic cost associated with the production of heat shock proteins [118] and as yet we have no knowledge of the effect of this in terms of altered transcription patterns in Antarctic species or how it will affect their response to climate change effects.
Well, admittedly, the Times said "demonstrable," not actually "demonstrated".
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