Notably, the causally demonstrable mechanisms of aging in Drosophila have proven to be different from the molecular mechanisms assumed by cell biologists from the 1950s to the 1990s, revolving instead around resistance to stress, investment in reproduction, and metabolic reserves.
We thus wondered if, by using PBMC, that is, in the presence of T-lymphocytes, some regulatory mechanisms may be demonstrable.
Well, admittedly, the Times said "demonstrable," not actually "demonstrated".
Earlier studies in the β2KO mice found that the contact sensitivity response and T-cell-dependent antibody response in β2KO compared with FVB mice were similar, despite defects demonstrable in isolated immune cells, but the mechanism of compensation was not identified (Sanders et al., 2003).
The Tulip classification, in addition to identifying a single demonstrable pathophysiological cause for the death, was also designed to identify the mechanism and the origin of the mechanism of the death, e.g. if the cause of an intrauterine death was attributed to infection, multiorgan failure would be considered the mechanism of the death and intrauterine infection the origin of the mechanism.
A clearly demonstrable association would provide impetus for further research on the underlying mechanisms with possible implications for the routine management of AKP problems and more widespread use of potential preventive strategies.
The molecular mechanisms of this activation are uncertain, but do not involve demonstrable mutations in β-catenin or Axin, unlike HCA [10].
Taken together, these data suggest that systemic levels of statins may approach levels that are toxic to spinal motoneurons and that particular mechanisms must account for the relatively infrequent occurrence of clinically demonstrable toxicity.
Furthermore, the lack of a demonstrable effect on daunorubicin binding to the plasma membrane by modulators points to transport mechanisms which do not utilise specific drug binding to the plasma membrane.
Non-injurious mechanical ventilation strategies interact with endotoxemia in mice to enhance pro-inflammatory mechanisms in the lungs and promote extra-pulmonary end-organ injury, even in the absence of demonstrable acute lung injury.
