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Overall, very few differences were observed in the comparisons between high grade serous carcinomas possessing mutation in BRCA1, mutation in BRCA2, epigenetic silencing of BRCA1, and no demonstrable loss in BRCA1.
So far, however, patients in many communities have undergone multiple courses of treatment over a period of 10 or more years without demonstrable loss of efficacy.
Both terms lack a firm definition, but we preferred PE because it encompasses clinically progressive conditions without demonstrable neuronal loss as well as those with a demonstrable loss of neural tissue, most often detected by magnetic resonance imaging (MRI) examination.
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Under the new rules, shrimp and crab fishermen are eligible for a final settlement equal to four times their demonstrable losses from 2010.
Under the formula, settlements would generally be double the demonstrable losses from 2010, with money previously paid by the fund subtracted.
Increased expression of miR-29a and miR-29b was seen in the combined group of carcinomas with any demonstrable BRCA1/2 loss compared to the group with no demonstrable BRCA1/2 abnormalities.
In the current study, miR-29a and miR-29b were found to be more highly upregulated in high grade serous carcinomas with any demonstrable BRCA1/2 loss compared to the group lacking demonstrable BRCA1/2 abnormalities by both microarray and qRT-PCR analyses.
Among respondents with and without diabetes, there was a demonstrable utility loss associated with hypoglycaemia.
Frozen tumors were available for all except two cases of serous carcinomas with no demonstrable BRCA1 loss (case number 208 and 273).
The gene expression profiles were also very similar between the groups, with only two genes showing significant differential expression when comparison was made between the group with BRCA1 mutation and the group with no demonstrable BRCA1 loss.
Although the device is prescribed primarily to alleviate deafness, enhancing the sound world of patients with demonstrable hearing loss can play a very important role in alleviating tinnitus [ 22– 25].
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