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Although the safety and haematological objectives of this study were supported by the data, certain conclusions about pharmacodynamics and efficacy endpoints, although plausible, were not demonstrable due to potentially high false-negative rates associated with smaller sample sizes (6 8 patients per treatment group).
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In 25 30% of the women the symptom of SUI is not demonstrable probably due to the artificial situation during the investigation [ 5].
It is unclear whether lack of a demonstrable benefit is due to problems with bioavailability of this specific formulation of curcumin or to inefficacy of curcumin as an intervention for AD.
Similarly, maternity waiting homes have not yet shown a demonstrable impact on stillbirths due to limitations in size and design of the studies on this subject.
It is proposed that although the same retinoblastoma cells in different circumstances are responsive to HPD-PDT, no clinical response is demonstrable utilizing this model, due to the absence of tumor vascularity.
It should be understood that these efforts have been going on for over a decade – at what point does this approach need reevaluation due to its demonstrable lack of effectiveness?
Lack of other demonstrable explanatory variables could be due to insufficient meta-analytic study power.
Private investors hold public transport in high regard, due to its demonstrable strengths, such as its stable revenue and cash flow, the clear potential for growth and its status as a provider of essential services.
Apart from the fact that "stimulus" can tend to be confused with "bailout," the public relations failure of the first stimulus package, Surowiecki argues, is actually due to its demonstrable success.
However, the absence of the demonstrable effect of quinapril may be due to several limitations in study design.
The display of antibodies on the surface of T lymphocytes, as a part of a chimeric-immune receptor (CIR) mediating signaling, may ideally link the antigen-antibody interaction to a demonstrable change in T cell phenotype, due to subsequent expression of the early T cell activation marker CD69.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com