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The CTV is defined as the demonstrable disease, plus a margin for sub-clinical spread.
Complete response (CR) was defined as complete regression of all measurable or evaluable disease including radiologically demonstrable disease, bone marrow involvement or peripheral blood involvement.
The remainder represent variants that, despite manifesting no demonstrable disease association, have nevertheless been shown to significantly alter the expression of a gene or the structure/function of the gene product.
Therapeutic efficacy has been demonstrated previously with the full-length MR1 anti-CD40L antibody [ 24], but the data presented here suggest that CDP7657, lacking any Fc-function, may have the potential to be an effective therapy in lupus patients with demonstrable disease.
Complete response (CR) was considered to be the complete disappearance of any sign of demonstrable disease, partial response (PR) as ⩾50% reduction of measurable disease and stable disease (SD) as a <50% reduction or a <25% increase in the sum of the products of the two perpendicular diameters of all measured lesions and the appearance of no new lesions for 8 weeks.
The following is an example of answers coded as a concept: To question A ("Do you think that it is a problem to decide whether there is a need for treatment in a case like this?" and if yes: "What problems?") informants gave answers like "there is no demonstrable disease, but the patient has symptoms" and "there is no diagnosis but a suffering patient" (patients 1 and 2).
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Previous population-based studies have demonstrated worsening breathlessness as functional status deteriorates, 33 even in the absence of demonstrable cardiorespiratory disease.
So far, at 61, I am free of demonstrable heart disease, as is my brother, who is 57.
Notably, 32% (8 out of 25) of samples had detectable MCV without demonstrable microscopic disease.
The results of CAST deterred physicians from using flecainide, even in patients without any demonstrable cardiovascular disease.
For this reason, and because of its proven benefit, almost all women diagnosed with early breast cancer will be offered some form of adjuvant therapy, which is therapy given after surgical resection in the absence of demonstrable residual disease.
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