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No standard-of-care with demonstrable clinical activity is recognised against which experimental treatments can be compared.
Recent figures suggest that <10% of new molecules reach the market primarily because of a lack of demonstrable clinical activity (Kola and Landis, 2004).
Flavone acetic acid (FAA) is extremely active against subcutaneous transplantable tumours in mice, but disappointingly there has been no demonstrable clinical activity.
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"Does that mean your writing is a cold and clinical activity?" "No, never clinical.
Older patients appear to have a significantly higher risk of demonstrable clinical varus laxity.
The AMG 108 program in OA was terminated because of lack of demonstrable clinical benefit.
For this lower concentration, a demonstrable clinical effect was recorded in terms of response rate.
Nonetheless, it has remained unclear whether the properties of hyperoncotic albumin can translate into demonstrable clinical benefits.
The lack of demonstrable clinical efficacy seen with this agent, as well as negative data from other studies of novel agents, was therefore disappointing.
Of course this quest can be hampered by the inexorable pursuit of demonstrable clinical effects of interventions founded upon gold standard methods.
A lung biopsy was suggested in this patient because, as pointed out in a number of previous reports, workers in glass fiber plants had no demonstrable clinical and roentgenologic pulmonary manifestations (e.g., Carel et al 2007).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com