The study by the National Academy of Sciences found that its approach had "meaningfully reduced drug expenditures without demonstrable adverse effects on quality".
Nitric oxide donor compounds have been clinically used in humans for decades and are well tolerated; headaches are the only demonstrable adverse effects, which depend on the dose and the route of administration.
Conclusions Delayed cord clamping, compared with early clamping, resulted in improved iron status and reduced prevalence of iron deficiency at 4 months of age, and reduced prevalence of neonatal anaemia, without demonstrable adverse effects.
Functionally, the increased ceramide accrual had a demonstrable and deleterious effect on myocardial mitochondrial respiration.
Thus, etomidate did not have a demonstrable adverse effect on outcome.
However, without a demonstrable adverse effect of PCB153 any possible ameliorating effects of fish could not be ascertained.
hK6 positivity had no demonstrable adverse effect on disease progression or on survival by univariate analysis, but did become statistically significant, giving a 3.5 and 5.5-fold increase in adverse risk, respectively, when the data were subjected to multivariate analysis.
But this does not mean that individual regulations have no demonstrable or adverse effects on employment within specific regions, industries, and firms.
"The absence of future wage increases, coupled with the effects of inflation, constitute a very demonstrable and adverse effect," the judge concluded.
Despite a modest increase in the number of diagnostic possibilities entertained by the clinician, no adverse effects were demonstrable on patient management following system use.
"We share the concerns expressed in the letter that some treatments labelled as complementary and alternative medicines have not been properly tested and are known to cause adverse effects, while others have no demonstrable benefits," said Professor David Read, the society's vice-president.
